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Contraindicated (one)pentobarbital will minimize the extent or effect of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Barbiturates can induce hepatic microsomal enzymes causing elevated metabolism and lessened anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); people st